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KMID : 0369820170470040357
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Jorunal of Korean Pharmaceutical Sciences
2017 Volume.47 No. 4 p.357 ~ p.364
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Zein-based solid dispersion for potential application in targeted delivery
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Nguyen Minh Ngoc Uyen
Tran Phuong Ha Lien
Tran Thao Truong Dinh
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Abstract
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The study aims to design and evaluate the ability of zein in solid dispersion (SD) system to enhance drug dissolution rate for a further application of colonic delivery of poorly water-soluble drug. The SD samples were prepared by solvent method and the investigation of drug release was performed at pH 7.4. The wettability, molecular interactions and drug’s crystal behaviours of SDs were studied by contact angle measurement, Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction (PXRD), respectively. Zein-based SDs showed its potential in enhancing the rate of drug release. The PXRD results pointed out a rearrangement of drug’s crystalline structure in some SD samples through the appearance of new peaks on PXRD diffractogram, while a formation of a hydrogen bond between prednisolone (PRL) and zein was also confirmed by FTIR spectra. It was evident that a strong relationship between the amount of zein and the dissolution rate of PRL in SD system attributed to zein hydrophobicity, recrystallization and molecular interaction which were factors inducing the enhanced drug release rate. In conclusion, zein is a potential carrier for controlled release SD systems, especially further application for poorly water-soluble drugs in colonic delivery like PRL due to the resistance of zein at low pH environment.
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KEYWORD
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Zein, Solid dispersion, Prednisolone, Controlled release, Colonic delivery
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